RNA-seq data demonstrated that Foc1 and Foc4 could modulate the expression of different Famotidine histidine kinase and response regulator genes. Relative to the vegetative growth stage, the more HKs were transcriptionally up regulated in Foc4 than in Foc1 at 48 h post inoculation to the banana ��Brazil��, while less HK genes were down regulated in Foc4 than in Foc1 at 48 h post inoculation to the banana ��Brazil��. Meanwhile, the expression of two RR genes was induced in Foc4, whereas none were affected in Foc1. These imply that more two-component signal transduction systems might be activated in Foc4 than in Foc1 during interaction between Foc4 and the banana host ��Brazil��. Of particular note, the counterpart of the virulence-associated genes CaSLN and MoSLN in Foc4 was transcriptionally induced, but that in Foc1 was repressed, suggesting that the pathogenicity associated two-component signaling could be activated. The protein kinases participate in a variety of cell processes and signal pathways including metabolism, cell signaling, protein regulation and other cellular pathways. We observed the variations in the expression of kinase genes between Foc1 and Foc4. Relative to the vegetative growth stage, Foc4 up-regulated more the protein kinase genes of AGC, CAMK and STE families than Foc1 during exposed to banana ��Brazil��. Following the signal transduction, the distinct TFs would be activated. Inspecting the transcription of TF genes, we found that more TF genes of C2H2, MYB, bHLH, bZIP, Winged helix repressor DNA-binding and nucleic acid-binding families were transcriptionally induced in Foc4 than in Foc1 at 48 hpi in comparison with the vegetative growth stage. The invasion growth Erythromycin Ethylsuccinate pathway is controlled by the mitogen activated protein kinase FMK1 and largely depends on the transcription factor Ste12, which mediates distinct outputs downstream of the FMK1 cascade. Although the expression of FMK1 was not induced in Foc1 and Foc4 at 48 h post inoculation as compared to that at vegetative growth stage, the transcripts level of Ste12 was increased in Foc4 but not in Foc1, indicating the invasion growth pathway was activated in Foc4 but not in Foc1 at pre-infection stage.