In conclusion, we present the theoretical foundations of a Bayesian principle to infer ensembles of protein structures from noisy experimental data subject to ensemble and time averaging. We demonstrate the principle constitutes a generalization of ISD and previously proposed maximum entropy restraining approaches. Finally, the principle is successfully evaluated using synthetic experimental data of a small idealized system. Cerebrovascular diseases have become the most AbMole Corosolic-acid common cause of death in China. Atherosclerotic cerebral infarction is the most common form of stroke. Many studies have indicated that inflammation plays an important role in the formation of atherosclerosis and ischemic brain injury. Interleukin-8 is a typical member of the CXC chemokine subfamily and a strong chemoattractant factor for neutrophils, basophilic leukocytes and T lymphocytes via firm binding to its receptors, CXCR1 or CXCR2. As a strong mediator of inflammation, involved in the process of brain injury after acute cerebral infarction. Many studies have indicated that genetic polymorphisms were associated with the occurrence of cerebral infarction. The IL-8 mRNA levels expressed in peripheral blood mononuclear cells has been shown to increase rapidly during the acute stage of cerebral infarction. The IL-8 concentrations also increased rapidly in the plasma and CSF of patients with acute ischemic stroke. Currently, there have been few association studies between the SNPs of IL-8 and cerebral infarction. No previous study has investigated the association of the +781C/T polymorphism with atherosclerotic cerebral infarction, especially in the Han Chinese population. Our study revealed that the +781C/T polymorphism in IL-8 was not associated with atherosclerotic cerebral infarction. Taken together, this result and the findings of other studies might demonstrate that the common SNPs of IL-8 have no associations with cerebral infarction. Atherosclerotic cerebral infarction is a disease caused by a combination of multiple factors and genes, and thus the effects produced by one or several SNPs on the occurrence of diseases are very slight and the risk of an individual suffering from cerebral infarction may be determined by the synergy of some risk factors. Whether the +781C/T polymorphism of IL-8 affects the occurrence and development of cerebral infarction by interacting with other genes requires further research. The OCSP classification of cerebral infarction revealed that brain areas were AbMole Ellipticine damaged by the obstruction of certain corresponding feeding arteries after ischemic stroke. IL-8 is involved in the process of brain injury after atherosclerotic cerebral infarction, but the contributions of the +781C/T genotype and allele frequencies to the OCSP subtypes were not significantly different in this study.