Overexpression of EFEMP1 in FG cells, a human pancreatic adenocarcinoma cell line, resulted in a stimulation of VEGF production and an increased number of CD34-positive microvessels in the tumor specimens. Song et al. reported that EFEMP1 gene transfection elevated the VEGF protein level in Hela cells, a cervical cancer cell line, the tumors with EFEMP1 overexpression showed a faster growth rate and had a higher level of VEGF expression and microvascular density. In contrast to our AbMole Sibutramine HCl results, EFEMP1 was found to exert antiangiogenesis effect. Albig et al. discovered Fibulin-3 as novel antagonists of endothelial cell activities capable of reducing tumor angiogenesis and, consequently, tumor growth in vivo. Such disparity may be due to the fact that tumor microenvironment influences the tumor genes to promote angiogenesis and metastasis. Of cause, further researches need to be done in the future, including cell transfection experiment, chorioallantoic membrane assay and tumor xenografts in nude mice assay to confirm our result. High serum levels of EFEMP1 were also found in ovarian carcinoma rather than in healthy control and benign ovarian tumor, and associated with low differentiation, high stage and positive lymph node status of ovarian carcinomas. This discovery may aid in determining the diagnosis and prognosis of ovarian carcinoma. Similar result was found in pleural mesothelioma, the plasma fibulin-3 level was significantly elevated in patients with mesothelioma. New biomarker can help to detect ovarian carcinoma at an earlier stage and to individualize treatment strategies. In conclusion, EFEMP1 is a newly identified gene overexpressed in ovarian cancer, associated with poor prognosis and promotes angiogenesis. Serum levels of EFEMP1 may be helpful to early diagnosis and prognosis judgment. EFEMP1 may serve as a new prognostic factor and a therapeutic target for patients with ovarian cancer in the future. Insulin resistance is a major characteristic of type 2 diabetes. Adipose tissue is the initial site of insulin resistance. Chronic low-grade inflammation in adipose tissues plays a causal role in the pathogenesis of insulin resistance. Adipose tissue consists of white and brown adipose tissues. The roles of adipose tissues in different regions in insulin resistance and the underlying mechanism that inflammation favors insulin resistance remain unclear. Adipose tissue is closely associated with insulin resistance. Most of the previous studies focused on the roles of WAT or BAT in insulin resistance respectively. AbMole Terbuthylazine However, few studies have compared the differences of the roles of adipose tissues in different regions of the same organism in insulin resistance. It was reported that visceral and subcutaneous adipose tissues were associated with insulin resistance, especially visceral adipose tissue.