Little is known about the bioavailability, absorption and metabolism of secondary metabolites of salix tree in humans and it is likely that different groups of compounds have different pharmacokinetic properties. The study reported here describes a simple mode of action of salicin and saligenin compounds to bind with the immature white blood cells only and destroy them with apoptosis associated DNA damage. Highly DNA damaged in leukemic cells incubated with salix extract was surprising when normal cells incubated with salix extract remained unaffected. Even D-Pantothenic acid sodium assuming unknown receptors in the surface of leukemic cells may be binding with salix extract compounds and leading to DNA destruction the mode of action of salicin and saligenin is not clear. The compounds from salix extract shown in Figure 5, will need more clinical experiments to elucidate the receptors and transduction pathways induced in leukemic cells. Gao and his coworker have investigated the resveratrol induced DNA fragmentation in 32Dp210 leukemic cells. Resveratrol induced apoptosis in 32Dp210 cells as supported by the induction of inter nucleosomal DNA fragmentation and the cleavage of procaspase-3 in resveratrol treated cells. These results supported the previously reported apoptosis-inducing activity of resveratrol against tumor cell lines. In conclusion the message from Arabian and Sennidin-B Middle East researchers to medical scientists over the world was to get back in nature and search for new drugs, to avoid the side effect of chemical therapy and to help patients recover from acute diseases. Because of small numbers, our post hoc analyses should be considered as tentative. The original human migration out of Africa occurred approx. 60,000 years ago, towards the Middle East and thereafter independently to Europe and Asia. The Americas were populated by humans of East Asian ancestry that crossed the Bering Strait, about 15 thousand years ago. These first Americans suffered a genetic bottleneck, and the reduced genetic diversity in Amerindians is evidenced in the absolute dominance of the O blood group among Amerindians, their low heterozygosity and the reduced number of mitochondrial DNA haplogroups.