Therefore, an alternative interesting question is: who needs an antidepressant, and how many of the patients who need an antidepressant do actually receive an antidepressant. This however, was not the focus of our study as undertreatment of depression has already been the focus of many studies in the past. Moreover, the NESDA study is not suitable for answering this question. It is a naturalistic study and part of the study population did not seek any help. It is therefore impossible to determine which patients are ‘‘undertreated’’ by their GP and which did not seek help for their psychological complaints. Multiple Sclerosis is a chronic debilitating central nervous system illness that is associated with a high unemployment rate in early adulthood. Inflammation,Etanercept demyelination and axonal damage are pathological hallmarks giving rise to the characteristic multifocal CNS lesions seen in MS. The symptoms that come along with having MS reflect the multifocal nature of the pathology, by showing a wide individual variation and severity. In dealing with the unpredictable nature of disease progression, the individual affected is left with a high degree of uncertainty about future occupational demands and work ability. The school-to-work transition may pose particular challenges for MS patients who are physically disabled or have a cognitive dysfunction. MS is one of the leading causes of non-traumatic disability affecting young adults in Europe and the USA, and the degree of physical disability has shown to be a strong predictor of work ability. Non-motor symptoms like pain, fatigue and memory impairment as well as demographic factors such as age and educational background have also shown significant impact on employment status in MS. Thus, Lambrolizumab employment may be regarded as a marker of overall functioning of the individual patient, and have also important impact on quality of life. Several studies have investigated and described demographic and clinical features associated with employment status in different cohorts of MS patients. However, we are not aware of any studies that have investigated employment status in a county based MS population and its subsequent clinical subtypes: relapsingremitting MS, secondary progressive MS and primary progressive MS.