The univariate analysis revealed a hospital mortality rate of 36.8%, with an odds ratio of 43.8. De Santo et al.evaluated 1,424 Clofentezine patients undergoing cardiac valve surgery and observed a 43.8% hospital mortality rate in patients classified as RIFLE�CFailure, with an odds ratio of 30. Even minimal changes in postoperative SCr were associated with a significant reduction in short and long-term survival. The SCr elevation might be associated with increased morbidity and mortality, even when the change did not exceed normal values. After cardiac surgery, AKI might occur in up to 48% of patientsand up to 9.6% of patients require RRT, particularly those with preoperative renal dysfunction. In our sample, 2% of patientsrequired RRT, in the first 7 postoperative days. Epidemiological studies have reported an RRT requirement of approximately 2.6% to 4.9%. Our lower incidence of RRT was associated with the fact that the need for dialysis treatment was evaluated only in the first seven days after surgery but the similarity of other studies suggests that although each center has different patient populations and criteria for indicating RRT, the average incidence of severe AKI requiring RRT is approximately 4%. In our study, the mortality of KDIGO stage 3 patients needing RRT peaked at 62%, in contrast with the mortality of patients without postoperative AKI. Although the mortality of patients treated with RRT after cardiac surgery declined, in most studies, this factor remained greater than 40%. We also found that age, female gender and CPB times are predictors of 30-day mortality after cardiac surgery. Age and female gender are traditional predictors of early and late mortality after cardiac surgery and are present in most contemporary operative risk scores. Many studies have found Pancuronium dibromide higher mortality rates after cardiac surgery in female genderbut not all. The higher mortality could be explained by differences in baseline characteristics such as older age, higher body mass index, more cardiovascular risk factors and comorbidities. Considering these possible confounders, we found that female gender was an independent risk factor for 30-day mortality after cardiac surgery. Cardiopulmonary bypass times were also implied to increase mortality after cardiac surgery. CPB is associated with significant hemodynamic changes, and the maintenance of cardiovascular stability during CPB requires the interplay between the function of the CPB machine and patient factors. Thus, any decrease in renal perfusion during CPB, depending on its magnitude and duration, can lead to significant cellular injury. Currently, only three studies have used the KDIGO classification to evaluate patients after cardiac surgery. In the first study, Ho et al.evaluated the change in SCrduring the first 6 hours after surgery in 350 patients undergoing CABG or CVS. The results showed that 14% of patients developed AKI according to the KDIGO criteria, with greater than 10% variation in SCr immediately after surgery, strongly associated with subsequent AKI after cardiac surgery. In the second study, Sampaio et al.evaluated the incidence and risk factors for AKI in 321 patients after cardiac surgery according to RIFLE, AKIN and KDIGO criteria. The incidence of AKI ranged from 15�C51%, and the adjusted Cox regression analysis revealed that only cases diagnosed, the requirement for RRT and prolonged hospitalization.