Simple regression analyses revealed that age, prior MI, NT-proBNP, creatinine, preprocedural cTnI, number of target vessels, number of B2/C type lesions, number of bifurcation lesions, number of predilation, number of postdilation, use of kissing balloon, maximum inflation pressure, number of stents and total stent length were positively associated with postprocedural cTnI levels, whereas high hemoglobin levels were associated with low postprocedural cTnI levels. Stepwise multivariable analysis revealed that factors independently associated with postprocedural cTnI levels were age, prior myocardial infarction, NT-proBNP, Geldanamycin-Biotin number of target vessels, number of postdilation and total stent length were positively associated with postprocedural cTnI levels, whereas HbA1c levels were inversely associated with postprocedural cTnI levels. The present study provided the first line of evidence that higher preprocedural HbA1c levels were associated with less risk of myocardial injury following elective PCI in diabetic patients. Thus, our study provided the novel finding regarding the relationship between preprocedural HbA1c and periprocedural myocardial injury. PCI has become an important strategy for patients with CAD. Patients with type 2 diabetes mellitus have a higher prevalence of CAD than the general population. Because of poor outcome, PCI in diabetic patients have been recognized as a complex procedure. With advances in PCI techniques and medications,L-742001 hydrochloride especially with introduction of drug-eluting stents, more and more diabetic patients receive PCI. However, PCI was still frequently companied with postprocedural cardiac marker elevation. There was a large body of data correlating troponin elevation after elective PCI with adverse clinical outcomes. Third universal definition of myocardial infarction has raised the diagnostic threshold of PCI-related myocardial infarction from the elevation of troponin above 3 times ULN to the elevation of troponin above 5 times ULN, and suggested that this threshold was arbitrarily chosen, based on clinical judgement and societal implications of the label of PCI-related myocardial infarction.