The process of vegetable tanning dates back to ancient times. In the process, the conversion of skin/hide matrix into leather is done through the crosslinking of plant polyphenols with the type I collagen matrix. Polyphenols interact with collagen through hydrophobic association and hydrogen bonding. The multiple hydroxyls functional groups present in the polyphenols will have the ability to have hydrogen bonding with the side functional groups and peptide backbone of collagen triple helices. Thus, crosslinked collagen matrices attain stability against Cimetidine enzymatic degradation. Based on conventional wisdom of vegetable tanning, we hypothesize the binding of polyphenols with type II collagen in AC and prevention of cartilage degradation. The most common characterized NES consists of a non-conserved motif made up of hydrophobic residues and is leucine-rich.Nucleocytoplasmic transport is a tightly monitored process regulated at many different stages.One mechanism of regulation includes importin protein expression, as different importins recognize different cargoes. Another mechanism of regulation involves alteration of sequence affinity to karyopherins, for example by phosphorylation of the signal sequence. A third mechanism of regulation involves intermolecular or intra molecular masking of signal sequences. This occurs through protein-protein interactions and conformational changes, respectively, which prevent signal recognition by karyopherins.In addition, non-conventional mechanisms exist which do not rely on importins/karyopherins but on interaction with other transporters, or through direct binding to nuclear pore complex components. RanBPM has been shown to interact with numerous proteins, implicating it in a variety of cellular Clozapine processes including cell adhesion, migration, microtubule dynamics, and gene transcription. It has been hypothesized that RanBPM functions as a scaffolding protein that may be part of a large complex. RanBPM has been identified as a phosphor protein and its phosphorylation is increased in response to stress stimuli, such as osmotic shock, ultraviolet light, and ionizing radiation.