A lack of statistical power might also explain why we could not observe differences in the incidence of postoperative organ dysfunction in the OPCAB-group despite a better preservation of the intraoperative selenium status. Furthermore we were unable to clarify whether the observed intraoperative selenium decrease in both groups was truly causative or only ����indicative���� for increased oxidative stress and the development of organ dysfunction. This question can only be resolved by a large-scale clinical trial in which the efficacy of an intraoperative selenium supplementation strategy has to be tested. Cytoplasmic linker proteins,microtubule-binding proteins, are involved in intracellular organization and organelle movement. In particular, several CLIP-170-related proteins, characterized by the presence of a cytoskeleton-associated protein-Gly motif that interacts with tubulin, are active at the organelle-microtubule interface. Recently, CLIPR-59, a new CLIP-170-related protein, has been identified, which is involved in the regulation of microtubule dynamics. In Salicyl alcohol addition to its microtubule binding, CLIPR-59 can also be associated with glycosphingolipid enriched microdomains on cell plasma membrane, i.e. with the so-called lipid rafts. It has been proposed that this kaempferol 3-neohesperidoside raft-associated CLIP could play a role at the raft-microtubule junction and in the regulation of membrane trafficking. Moreover, recent evidence showed that CLIPR-59 functions as a scaffold protein that interacts with phosphoAkt and regulates Akt cellular compartmentalization. The role of CLIPR-59 in the regulation of signal transduction pathway is related to its association with lipid rafts on the cell surface. Indeed, the last 30 amino acids of CLIPR-59 are required to target it to the plasma membrane and a double palmitoylation on tandem cysteines within this domain is responsible for the raft targeting. Lipid rafts have been associated with several cell functions, including cell death. It has in fact been suggested that lipid rafts could play a key role in receptor-mediated apoptosis of T cells.